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Resources on Liver Education, Care and Research

A variety of resources to educate yourself about liver care and liver diseases, as well research on these topics.  Explore research performed by             Dr. Kowdley. In addition, we have included a list of Calculators. Read about Fibroscan exams to check your liver. 

Liver Disease Information

These are websites that provide general information about the liver as well as liver health and liver diseases.

     American Liver Foundation  https://liverfoundation.org

     NIH-NIDDK  https://www.niddk.nih.gov/about-niddk/research-areas/liver-disease

     NIH-NIDDK, NASH  https://repository.niddk.nih.gov/studies/nash/

Calculators

The following calculators are algorithms with formulas. They designed for different disease states to provide prognosis.

Globe PBC calculates short and long term survival likelihood.

     https://www.globalpbc.com/globe

NFS (NAFLD Fibrosis Score) uses variables such as age, blood tests, etc to produce a number. This number on a scale helps to estimate the amount of scarring in the liver.

     https://nafldscore.com/

FIB4 (Fibrosis-4) score helps to estimate the amount of scarring in the liver.

     https://www.hepatitisc.uw.edu/page/clinical-calculators/fib-4

Fatty Liver Index

     https://www.mdcalc.com/fatty-liver-index

PSC

     https://www.mayoclinic.org/medical-professionals/transplant-medicine/calculators/the-revised-natural-history-model-for-primary-sclerosing-cholangitis/itt-20434725

PSC This is the Amsterdam-Oxford PSC score calculator.  It uses routinely available clinical and laboratory data and predicts liver transplant-free survival in PSC.  This test was designed to avoid bias from prognostic models from tertiary referral centers. Data from Amsterdam and Oxford based on hundreds of PSC patients was used to derive the score. It uses type of PSCC (small vs large duct), age at PSC diagnosis and some blood test results to calculate a score that can provide information about transplant survival.

     http://www.fcbkapp.nl/psc/8/

HOMA IR

     https://www.mdcalc.com/homa-ir-homeostatic-model-assessment-insulin-resistance

Fibroscan

A Fibroscan is vibration-controlled transient elastography and is a non-invasive method to measure liver stiffness. Liver stiffness may be increased by many factors, including scarring (which may be a sign of cirrhosis) fatty infiltration of the liver, or inflammation.

Transient elastography has replaced liver biopsy in many situations in the treatment and management of liver disease. This procedure has been available in Europe for many years and is very useful in identifying presence or absence of significant (heavy) scarring in the liver in many liver diseases such as chronic hepatitis B or chronic hepatitis C, as well as primary biliary cholangitis or primary sclerosing cholangitis. It has replaced liver biopsy as a means of staging the degree of scarring or fibrosis in the liver in these conditions. Transient elastography is also useful to estimate the amount of fat in the liver and has become an important test in fatty liver disease or NASH to identify patients who may have significant fat and scarring in the liver.  (University Health Network, University of Toronto)

The procedure takes about 3-5minutes and is done in the clinic. No preparation is required and the results are immediate.

Research